eMAI™ PHMB and PHMG Biocides: Using the Next Generation of Polyguanidine Antimicrobials

PHMB and PHMG are cationic polymeric biocides whose guanidinium groups adsorb onto microbial surfaces and disrupt essential membrane functions. PHMB contains a biguanide structure and can act on the cytoplasmic phospholipid bilayer through transmembrane transport, while PHMG is based on a monoguanidine structure and forms a surface film that interferes with microbial respiration and membrane integrity.

Both offer broad-spectrum activity, low-dose effectiveness, durable control, thermal stability, and good formulation compatibility, with typical uses in water treatment, hygiene, industrial processing, and other controlled antimicrobial applications.

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